منابع مشابه
Tumor microenvironment in cancer progression
Keywords: tumor microenvironment; Heat-shock Factor 1 (HSF1) Billions of years of evolution through changing environments led organisms to develop an arsenal of cytoprotec-tive pathways to promote their survival under stressful conditions. We hypothesized that tumors exploit these mechanisms to support their own survival as they rapidly develop and evolve in a hostile and stressful environment....
متن کاملIntercellular Communication, the Tumor Microenvironment, and Tumor Progression
Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct...
متن کاملImmune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy
The tumor microenvironment plays a critical role in cancer development, progression, and control. The molecular and cellular nature of the tumor immune microenvironment influences disease outcome by altering the balance of suppressive versus cytotoxic responses in the vicinity of the tumor. Recent developments in systems biology have improved our understanding of the complex interactions betwee...
متن کاملTumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy
Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. Different etiological factors such as hepatitis B and C virus, alcohol and diabetes cause liver injury followed by inflammation, necrosis and hepatocytes proliferation. Continuous cycles of this destructive-regenerative process culminates in liver cirrhosis which is characterized by regenerati...
متن کاملTumor microenvironment controls the rate of cancer progression and metastasis
Tumors are unorganized organs that contain many different cell types that communicate with cancer cells (Kalluri NRC 2006). The central goal of our laboratory is to evaluate the role of these non-cancer cells in cancer progression and metastasis. Cancer progression significantly depends on the influence of many different host cells. Whether such host responses are recruited to control cancer pr...
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ژورنال
عنوان ژورنال: Journal of Surgical Oncology
سال: 2011
ISSN: 0022-4790
DOI: 10.1002/jso.21709